Tardif R, Sato A, Laparé S, Brodeur J
Département de médecine du travail et d'hygiène du milieu, Faculté de médecine, Université de Montréal, Québec, Canada.
Occup Environ Med. 1994 Mar;51(3):187-91. doi: 10.1136/oem.51.3.187.
This study was undertaken to determine whether previous subacute treatment with ethanol could modify the kinetics of m-xylene in humans. A group of six volunteers was exposed twice to either 100 or 400 ppm of m-xylene during two hours (between 0800 and 1000). Ethanol was given orally in the early evening on each of two consecutive days before exposures (total ethanol intake of 137 g). Such ethanol pretreatment affected the kinetics of m-xylene but only at the high exposure (400 ppm). The modifications were: (1) decreased concentration of m-xylene in blood and alveolar air during and after exposure; (2) increased urinary excretion of m-methylhippuric acid at the end of exposure. Ethanol treatment also enhanced the elimination of antipyrine in saliva. Overall, this study showed that the effect of enzyme induction on the metabolism of m-xylene, after ethanol ingestion, depends on the exposure concentration and is not likely to occur as long as the exposure concentrations remain under the current maximum allowable concentration (100 ppm) in the workplace.
本研究旨在确定先前用乙醇进行的亚急性治疗是否会改变人体中间二甲苯的动力学。一组六名志愿者在两小时内（08:00至10:00之间）两次暴露于100或400 ppm的间二甲苯中。在每次暴露前连续两天的傍晚口服乙醇（乙醇总摄入量为137克）。这种乙醇预处理影响了间二甲苯的动力学，但仅在高暴露（400 ppm）时。这些改变包括：（1）暴露期间和暴露后血液和肺泡气中间二甲苯浓度降低；（2）暴露结束时间甲基马尿酸的尿排泄增加。乙醇治疗还增强了唾液中安替比林的消除。总体而言，本研究表明，乙醇摄入后酶诱导对间二甲苯代谢的影响取决于暴露浓度，只要工作场所的暴露浓度保持在当前最大允许浓度（100 ppm）以下，就不太可能发生这种影响。
