Smokovitis A
Thromb Haemost. 1980 Jun 18;43(2):141-6.
Branching regions of the aorta are predilection regions for atherosclerosis. The intima in the branching regions of the normal aorta shows a constantly increased plasminogen activator activity from early life. At these areas, the endothelium is also damaged, it shows increased permeability, etc. The constantly increased plasminogen activator activity (local plasmin production) might play a protective role or on the might participate in the initiation of atherosclerosis at the branching regions through a number of proved or suggested mechanisms. No matter what the actual role of the locally increased plasminogen activator activity in the initiation of atherosclerosis is, the role of the fibrinolytic system in the progression of the atherosclerotic lesion seems to be clear. There is an accumulation of evidence that the impaired fibrinolytic activity in atherosclerotics participates in the progression and the complications of the disease.
主动脉的分支区域是动脉粥样硬化的好发部位。正常主动脉分支区域的内膜从早年起就呈现出持续升高的纤溶酶原激活物活性。在这些区域，内皮也会受损，表现出通透性增加等情况。持续升高的纤溶酶原激活物活性（局部纤溶酶生成）可能发挥保护作用，也可能通过一些已证实或推测的机制参与主动脉分支区域动脉粥样硬化的起始过程。无论局部纤溶酶原激活物活性升高在动脉粥样硬化起始过程中的实际作用如何，纤维蛋白溶解系统在动脉粥样硬化病变进展中的作用似乎是明确的。有越来越多的证据表明，动脉粥样硬化患者纤溶活性受损参与了疾病的进展和并发症。
