Falk H, Herbert J T, Edmonds L, Heath C W, Thomas L B, Popper H
Cancer. 1981 Jan 15;47(2):382-91. doi: 10.1002/1097-0142(19810115)47:2<382::aid-cncr2820470228>3.0.co;2-n.
Four cases of childhood hepatic angiosarcoma (HAS), representing the malignant form of infantile hemangioendothelioma, are described. The morphologic appearance of childhood HAS differs from the adult form in the following features: the associated presence of benign infantile hemangioendothelioma; the presence of dysontogenetic features; and an altered appearance of the angiosarcoma itself. It is postulated for these cases that the benign infantile hemangioendothelioma progressed to the malignant angiosarcoma. One of the four cases had exposure to elevated levels of arsenic in the environment that may have contributed to this progression. This latter case adds to published reports associating arsenic exposure with increased risk for hepatic angiosarcoma.
本文描述了4例儿童肝血管肉瘤（HAS），其为婴儿型血管内皮瘤的恶性形式。儿童HAS的形态学表现与成人型在以下特征方面有所不同：伴有良性婴儿型血管内皮瘤；存在发育异常特征；血管肉瘤本身外观改变。推测这些病例中良性婴儿型血管内皮瘤进展为恶性血管肉瘤。4例中的1例曾暴露于环境中高水平的砷，这可能促成了这种进展。后一病例补充了已发表的将砷暴露与肝血管肉瘤风险增加相关联的报告。
