Schutte P K, Beales D L, Dalton R
J Laryngol Otol. 1981 Jan;95(1):17-22. doi: 10.1017/s0022215100090356.
The general practice records of 68 children with secretory otitis media (SOM) were studied. A control group was matched one-for-one on the basis of sex, year of birth and general practice list. The SOM group had twice the incidence of recorded atopy, twice the incidence of recorded previous upper respiratory tract infections (URTI), and three times the incidence of recorded attacks of acute otitis media (AOM) compared with the control group. The recorded antibiotic treatment of URTI and AOM in the two groups was similar. Antihistamines and decongestants were seldom recorded in the treatment of AOM. The higher incidence of atopy found in the children with SOM prompts the suggestion that antihistamines and decongestants used by general practitioners in the routine treatment of AOM and URTI might help prevent the development of SOM. A prospective double-blind trial along these lines seems desirable.
对68例分泌性中耳炎（SOM）患儿的全科医疗记录进行了研究。对照组根据性别、出生年份和全科医疗名单进行一对一匹配。与对照组相比，SOM组记录的特应性疾病发病率是对照组的两倍，记录的既往上呼吸道感染（URTI）发病率是对照组的两倍，记录的急性中耳炎（AOM）发作发病率是对照组的三倍。两组记录的URTI和AOM抗生素治疗情况相似。在AOM治疗中很少记录使用抗组胺药和解充血剂。SOM患儿中发现的特应性疾病发病率较高，这提示全科医生在AOM和URTI常规治疗中使用抗组胺药和解充血剂可能有助于预防SOM的发生。进行一项沿此思路的前瞻性双盲试验似乎是可取的。
