Meerson F Z, Lifshits R I, Pavlova V I
Vopr Med Khim. 1981 Jan-Feb;27(1):35-9.
Effect of emotional-painful stress (EPS) on activity of the gamma-aminobutyric acid (GABA) system was studied in animal brain hemispheres and heart muscle. Activation of the GABA-system, developed in brain and heart tissues after EPS, exhibited various physiological importance in the tissues. In brain tissue activation of the GABA-system occurred together with inhibition of FAD-dependent oxidation of succinate in tricarboxylic acid cycle and therefore it might lead to an increased accumulation of the inhibitory metabolite gamma-hydroxybutyric acid, which is important in limitation of the stress stimulation. In heart muscle activation of the GABA-system was realized simultaneously with an increase in FAD-dependent oxidation of succinate and could represent the shunt, which enables to produce the additional amount of succinate, in spite of inhibition of NAD-dependent oxidation of alpha ketoglutarate in tricarboxylic acid cycle. The functioning of the GABA-system as the shunt, responsible for high intensity of FAD-dependent oxidation, might be important both in sufficient resynthesis of ATP in heart muscle and in formation of additional amount of NADPH, essential for biosynthesis.
在动物脑半球和心肌中研究了情绪性疼痛应激（EPS）对γ-氨基丁酸（GABA）系统活性的影响。EPS后在脑和心脏组织中发生的GABA系统激活，在组织中表现出各种生理重要性。在脑组织中，GABA系统的激活与三羧酸循环中琥珀酸的FAD依赖性氧化抑制同时发生，因此可能导致抑制性代谢物γ-羟基丁酸的积累增加，这对于限制应激刺激很重要。在心肌中，GABA系统的激活与琥珀酸的FAD依赖性氧化增加同时实现，并且可以代表分流，尽管三羧酸循环中α-酮戊二酸的NAD依赖性氧化受到抑制，但仍能够产生额外量的琥珀酸。作为负责高强度FAD依赖性氧化的分流器，GABA系统的功能可能对于心肌中ATP的充分再合成以及生物合成所必需的额外量NADPH的形成都很重要。
