Rozanov V A, Tsepkolenko V A, Levitskiĭ M V, Galich I M, Promyslov M Sh
Zh Vopr Neirokhir Im N N Burdenko. 1988 Sep-Oct(5):11-5.
A severe compression craniocerebral trauma was induced in rats under short-term halothane anesthesia. The activity of pyruvate and 2-oxoglutarate dehydrogenase complexes reduced significantly in the tissue of the damaged hemisphere, ALT activity increased sharply, AST activity grew slowly, the production of GABA in the glutamate decarboxylase reaction was slightly inhibited and its utilization in the GABA transaminase reaction was clearly accelerated. The GABA level in the nerve tissue showed a tendency to reduce, while the glutamate level had a tendency to increase. The observed changes are evidence that the inclusion of the GABA skeleton in the reaction of further oxidation intensifies, which may be of significance in compensation of the transport of the energetically oxidizing succinate and, possibly, in the formation of endogenous GABA possessing a stress-relieving effect.
在短期氟烷麻醉下诱导大鼠发生严重的压迫性颅脑创伤。受损半球组织中丙酮酸脱氢酶复合体和2-氧代戊二酸脱氢酶复合体的活性显著降低，谷丙转氨酶（ALT）活性急剧升高，谷草转氨酶（AST）活性缓慢升高，谷氨酸脱羧酶反应中γ-氨基丁酸（GABA）的生成略有抑制，而其在GABA转氨酶反应中的利用明显加速。神经组织中的GABA水平呈降低趋势，而谷氨酸水平呈升高趋势。观察到的这些变化表明，GABA骨架参与进一步氧化反应的过程增强，这可能在补偿高能氧化型琥珀酸的转运以及可能在内源性具有缓解应激作用的GABA的形成中具有重要意义。
