Ouaissi M A, Haque A, Capron A
Parasitology. 1981 Feb;82(1):55-62. doi: 10.1017/s003118200004186x.
The in vitro interaction between rat peritoneal macrophages and Dipetalonema viteae microfilariae in the presence of amicrofilaraemic rat immune serum was studied by transmission electron microscopy. The probable sequence of events leading to the killing of D. viteae microfilaria by macrophages is as follows. (a) Rat peritoneal macrophages in the presence of amicrofilaraemic rat immune serum adhere to the parasite surface, (b) the macrophages extend their pseudopodia around the parasite, (c) the 'lysosome-like' granules discharge their contents on to the parasite surface, (d) the lytic activity of these products begins at the parasite surface and (e) subsequent breaking of the microfilarial cuticle occurs, exposing the parasite intracellular material.
运用透射电子显微镜研究了在无微丝蚴血症大鼠免疫血清存在的情况下，大鼠腹腔巨噬细胞与魏氏棘唇线虫微丝蚴之间的体外相互作用。巨噬细胞杀死魏氏棘唇线虫微丝蚴的可能事件顺序如下：(a) 在无微丝蚴血症大鼠免疫血清存在的情况下，大鼠腹腔巨噬细胞黏附于寄生虫表面；(b) 巨噬细胞围绕寄生虫伸出伪足；(c) “溶酶体样”颗粒将其内容物释放到寄生虫表面；(d) 这些产物的溶解活性始于寄生虫表面；(e) 随后微丝蚴角质层破裂，暴露出寄生虫的细胞内物质。
