Rudeen P K, Symmes S K
Pharmacol Biochem Behav. 1981 Feb;14(2):143-7. doi: 10.1016/0091-3057(81)90234-3.
Male golden hamsters preferentially consume alcohol solution when given a free-choice between water and the alcohol solution. The pineal gland has been implicated as influencing the predilection for the ethanol solution. Melatonin, a pineal hormone, was administered either daily for 11 weeks as a subcutaneous injection (25 micrograms/animal) or weekly as a subcutaneous beeswax implant (1 mg melatonin/24 mg beeswax) for 5 weeks to hamsters allowed a free-choice between water or a 10% ethanol solution. Food, water and alcohol consumptions were measured on a daily basis. Animals treated by daily injection with melatonin consumed slightly less ethanol than animals not given melatonin. In light-deprived animals given chronic implants of melatonin, alcohol consumption was reduced when compared to alcohol consumption by light-deprived hamsters not receiving melatonin. Melatonin treatment also resulted in reducing daily total fluid intake as well as ethanol consumption in light-deprived hamsters. The results indicate that the pineal gland may influence fluid consumption in the hamster, and indirectly alters the propensity of the hamster to consume alcohol.
当在水和酒精溶液之间进行自由选择时，雄性金黄仓鼠优先选择饮用酒精溶液。松果体被认为会影响对乙醇溶液的偏好。褪黑素是一种松果体激素，对允许在水或10%乙醇溶液之间自由选择的仓鼠，以皮下注射的方式每日给药（25微克/只动物）持续11周，或者以皮下植入蜂蜡的方式每周给药（1毫克褪黑素/24毫克蜂蜡）持续5周。每天测量食物、水和酒精的摄入量。每日注射褪黑素治疗的动物比未注射褪黑素的动物摄入的乙醇略少。在长期植入褪黑素的光剥夺动物中，与未接受褪黑素的光剥夺仓鼠相比，酒精摄入量减少。褪黑素治疗还导致光剥夺仓鼠的每日总液体摄入量以及乙醇摄入量减少。结果表明，松果体可能影响仓鼠的液体摄入，并间接改变仓鼠饮用酒精的倾向。
