Ziegler W J
Arzneimittelforschung. 1980;30(11b):2073-4.
In a review study including altogether 5 clinical trials with a total of 221 hyperlipidaemic patients the influence of 1-(theophyllin-7-yl)-ethyl-2-[2-(p-chlorophenoxy)-2-methylpropionate] (etofylline clofibrate, Duolip) treatment on serum uric acid level was investigated. 73 patients thereof, i.e., one-third of the hyperlipidaemic patients, had increased values of uric acid. In all studies a statistically significant and clinically relevant uricosuric activity was established.
在一项总计纳入5项临床试验、共221例高脂血症患者的综述研究中,调查了1-(茶碱-7-基)-乙基-2-2-(对氯苯氧基)-2-甲基丙酸酯治疗对血清尿酸水平的影响。其中73例患者,即三分之一的高脂血症患者,尿酸值升高。在所有研究中均确立了具有统计学意义且临床相关的促尿酸尿活性。