Scherhag R
Fortschr Med. 1983 Sep 22;101(36):1635-7.
During an 8-months treatment period the effect of Duolip on serum uric acid in 112 patients with hyperlipidemia was studied. In this open clinical trial a long-lasting hypouricemic effect could be shown for Duolip. This response was more pronounced with higher initial serum uric acid concentrations and could only be observed in patients with serum uric acid levels above 6.4 mg%. Thus, in one patient both risk factors of atherosclerosis--hyperlipidemia and hyperuricemia--can be treated by a single drug.
在为期8个月的治疗期内,研究了多利普对112例高脂血症患者血清尿酸的影响。在这项开放性临床试验中,多利普可显示出持久的降尿酸作用。这种反应在初始血清尿酸浓度较高时更为明显,且仅在血清尿酸水平高于6.4mg%的患者中观察到。因此,单一药物可治疗动脉粥样硬化的两个危险因素——高脂血症和高尿酸血症。