Maier-Lenz H, Ringwelski L, Windorfer A
Arzneimittelforschung. 1981;31(1):105-9.
After the single-dose application of Migräne-Kranit, a combination of caffeine, ethaverine, propyphenazone, paracetamol and phenobarbital, tablets and suppositories in six healthy male volunteers aged from 24 to 28 years, serum concentrations were determined. The estimated relative bioavailabilities of the single substances in the suppository formulation vary between 120% for propyphenazone and 83% for phenobarbital in comparison to the tablets. The lag-times and the absorption rates for the substances in both formulations differ significantly. The absorption rates for the substances in the tablet are faster than for those in the suppository. The estimates for the elimination rates show only small differences between the two formulations.
在6名年龄在24至28岁的健康男性志愿者单次服用Migräne-Kranit（一种含有咖啡因、依沙维林、丙氧苯宗、对乙酰氨基酚和苯巴比妥的片剂和栓剂组合）后，测定了血清浓度。与片剂相比，栓剂制剂中单一物质的估计相对生物利用度在丙氧苯宗的120%至苯巴比妥的83%之间变化。两种制剂中这些物质的滞后时间和吸收速率有显著差异。片剂中物质的吸收速率比栓剂中的快。两种制剂的消除速率估计仅显示出微小差异。
