Wendler D
Anat Anz. 1980;148(4):295-308.
The paper describes pathohistological events after damaging of fetal blastemas by the cytotoxic agent cyclophosphamide in the rat. Fetuses were investigated at 24 hours intervals after application of cyclophosphamide (20 mg/kg body weight) on day 15 p. c. to detect the time of injury and reparation. During the first 24 hours heavy degenerations are seen in the central nervous system. Especially, dorsal parts of brain regions (alar plate derivatives) and certain mesenchymal structures (skin of the trunk, eye lids, auricle, mesenchyme of touch hairs) are affected. Moreover, 48 hours after damaging repairing processes are parallel to necrobiotic events. Resorption of necrotic cell detritus takes place by fetal macrophages and the primitive cerebral liquor. After 72 hours only repairing processes are to be seen. Structural defects in certain brain regions and in mesenchymal parts of the body (skin, palatal processes, eye lids, auricle) are the final results of cell injury and determine the typical malformation syndrome in the rat.
本文描述了大鼠中细胞毒性药物环磷酰胺损伤胎儿胚基后的病理组织学变化。在妊娠第15天给大鼠腹腔注射环磷酰胺（20mg/kg体重），之后每隔24小时对胎儿进行检查，以检测损伤和修复的时间。在最初的24小时内，中枢神经系统出现严重变性。特别是，脑区的背侧部分（翼板衍生物）和某些间充质结构（躯干皮肤、眼睑、耳廓、触须间充质）受到影响。此外，损伤后48小时，修复过程与坏死过程同时进行。胎儿巨噬细胞和原始脑液对坏死细胞碎屑进行吸收。72小时后，仅可见修复过程。某些脑区和身体间充质部分（皮肤、腭突、眼睑、耳廓）的结构缺陷是细胞损伤的最终结果，并决定了大鼠典型的畸形综合征。
