Becker W J, Watters G V, Humphreys P
Neurology. 1981 May;31(5):555-60. doi: 10.1212/wnl.31.5.555.
Three children, age 2, 7, and 12, developed Fisher syndrome: inability to walk because of ataxia, complete areflexia, and ophthalmoplegia. Ptosis was prominent in all the children, but the pupillary response to light was affected only in one child. Limb weakness was never present, and sensation normal. One patient was obtunded for several days. Two had prodromal upper respiratory tract illnesses, and the third patient was bitten by an insect 2 days before her symptoms began. Cerebrospinal fluid (CSF) protein content was moderately increased in all patients, but only one child's CSF had a pleocytosis. CSF gamma globulin levels were normal. In the acute phase, F waves and H responses were absent in two cases but returned to normal with clinical recovery. All three patients had marked electroencephalographic (EEG) abnormalities that later improved. The EEG pattern suggested a brainstem disorder. These findings plus the obtundation, gaze paralysis, and ataxia indicate that in Fisher syndrome there is parenchymal involvement of the central nervous system with or without nerve root involvement.
三名儿童，年龄分别为2岁、7岁和12岁，患上了费舍尔综合征：因共济失调而无法行走、完全性反射消失以及眼肌麻痹。所有儿童均有明显的上睑下垂，但只有一名儿童的瞳孔对光反应受到影响。从未出现肢体无力，感觉正常。一名患者昏迷了几天。两名患者前驱有上呼吸道疾病，第三名患者在症状出现前2天被昆虫叮咬。所有患者的脑脊液（CSF）蛋白含量均中度升高，但只有一名儿童的脑脊液有细胞增多。脑脊液γ球蛋白水平正常。急性期，两例患者的F波和H反射消失，但随着临床恢复而恢复正常。所有三名患者均有明显的脑电图（EEG）异常，随后有所改善。脑电图模式提示脑干疾病。这些发现加上昏迷、凝视麻痹和共济失调表明，在费舍尔综合征中，中枢神经系统存在实质性受累，伴或不伴有神经根受累。
