Wallnau L B, Bordash G D, Corso P
Pharmacol Biochem Behav. 1981 Apr;14(4):469-73. doi: 10.1016/0091-3057(81)90304-x.
Treatment with the dopamine (DA) receptor blocker, haloperidol, enhanced tonic immobility (TI) duration. Fenfluramine, a receptor agonist for serotonin (5-HT), reversed this effect. Tryptophan produced long TI reactions, and is believed to do so due to impaired synaptic transmission of 5-HT following its direct inhibitory effects on 5-HT neurons. DA receptor stimulation by apomorphine prevented the tryptophan potentiation of tonic immobility. The results suggest that serotonergic and dopaminergic systems may interact with respect to tonic immobility.
使用多巴胺（DA）受体阻滞剂氟哌啶醇进行治疗可延长强直性静止（TI）的持续时间。芬氟拉明是一种血清素（5-羟色胺，5-HT）受体激动剂，可逆转这种效应。色氨酸会产生长时间的TI反应，据信这是由于其对5-HT神经元的直接抑制作用导致5-HT的突触传递受损所致。阿扑吗啡对DA受体的刺激可防止色氨酸增强强直性静止。结果表明，血清素能和多巴胺能系统可能在强直性静止方面相互作用。
