Wallnau L B
Pharmacol Biochem Behav. 1981 Dec;15(6):895-901. doi: 10.1016/0091-3057(81)90050-2.
Acute administration of morphine (2 mg/kg, IM) enhanced tonic immobility (TI) durations in three-week old chickens. This effect could be reversed with the 5-HT receptor agonist quipazine. Similarly, promoting 5-HT release by fenfluramine antagonized the morphine potentiation of the response. Both 5-HT agonists reduced TI durations. Finally, the DA receptor agonist apomorphine produced decrements in TI duration and blocked the effect of morphine. The results suggest the involvement of serotonergic and dopaminergic mechanism in the morphine potentiation of the response. The findings are also discussed in terms of a revised serotonergic model of tonic immobility.
对三周龄雏鸡急性注射吗啡（2毫克/千克，肌肉注射）可延长其强直性静止（TI）时间。5-羟色胺（5-HT）受体激动剂喹哌嗪可逆转这种效应。同样，芬氟拉明促进5-HT释放可拮抗吗啡对该反应的增强作用。两种5-HT激动剂均缩短了TI时间。最后，多巴胺（DA）受体激动剂阿扑吗啡可缩短TI时间，并阻断吗啡的作用。结果表明，5-羟色胺能和多巴胺能机制参与了吗啡对该反应的增强作用。本文还根据修订后的强直性静止5-羟色胺能模型对这些发现进行了讨论。
