Wallnau L B, Bordash G D, Corso P
Pharmacol Biochem Behav. 1981 Apr;14(4):463-8. doi: 10.1016/0091-3057(81)90303-8.
The effects of serotonergic manipulations on tonic immobility (TI) were examined. Systemic injections of tryptophan enhanced TI duration. This effect was reversed by quipazine, a 5-HT receptor agonist, and p-chloroamphetamine, a 5-HT releaser. Separately, these drugs caused marked reductions in TI duration. Fenfluramine, which promotes 5-HT release, also reduced TI duration. The quipazine attenuation of TI was prevented by pretreatment with the 5-HT receptor blocker cinanserin. The results are discussed in terms of 5-HT receptor mechanisms and the raphe model of tonic immobility.
研究了5-羟色胺能操作对强直性静止（TI）的影响。全身性注射色氨酸可延长TI持续时间。这种作用可被5-羟色胺受体激动剂喹哌嗪和5-羟色胺释放剂对氯苯丙胺逆转。另外，这些药物可显著缩短TI持续时间。促进5-羟色胺释放的芬氟拉明也可缩短TI持续时间。TI的喹哌嗪减弱作用可被5-羟色胺受体阻断剂辛那色林预处理所阻止。根据5-羟色胺受体机制和强直性静止的中缝核模型对结果进行了讨论。
