Miettinen T A
Ann Clin Res. 1980 Dec;12(6):295-8.
Determination of a 24-hour lipoprotein lipid profile on a mixed diet showed a typical increase in VLDL (includes chylomicrons) lipids following food intake in normal subjects. The change was less marked or absent in patients with jejuno-ileal by-pass and after cholestyramine treatment of a case with post-ileal-resection diarrhoea. Triglycerides of other lipoproteins did not fluctuate very much but free and esterified cholesterol of LDL and HDL showed a significant diurnal variation: lowest values were seen early in the morning followed by an increase before breakfast, with the highest levels during the afternoon in most cases. No clearcut precursor-product relationship could be seen between VLDL and LDL or HDL, yet the rhythmic changes in the VLDL levels and/or in cholesterol synthesis may be causally associated with the diurnal variation of cholesterol in LDL and HDL.
对正常受试者混合饮食下24小时脂蛋白脂质谱的测定显示，进食后极低密度脂蛋白（包括乳糜微粒）脂质典型增加。空肠回肠旁路术患者以及用消胆胺治疗回肠切除术后腹泻患者的这种变化不太明显或没有变化。其他脂蛋白的甘油三酯波动不大，但低密度脂蛋白和高密度脂蛋白的游离胆固醇和酯化胆固醇有显著的昼夜变化：清晨值最低，早餐前升高，大多数情况下下午水平最高。在极低密度脂蛋白与低密度脂蛋白或高密度脂蛋白之间未见明确的前体-产物关系，但极低密度脂蛋白水平和/或胆固醇合成的节律性变化可能与低密度脂蛋白和高密度脂蛋白中胆固醇的昼夜变化存在因果关联。
