Stoner G L, Belehu A, Nsibambi J, Warndorff J
Int J Lepr Other Mycobact Dis. 1981 Mar;49(1):16-20.
Borderline tuberculoid leprosy was diagnosed clinically and histologically in a four year-old boy about 6 months after intradermal vaccination with BCG. His mother reported that a lesion began to appear above the vaccination site on the arm 2 weeks after the vaccination, and a second lesion appeared on the chin 2 months later. Responses in the lymphocyte transformation test to sonicated Mycobacterium leprae, BCG, and to PPD were consistent with a tuberculoid leprosy infection. Precipitation of BT leprosy by intradermal BCG infection may possibly represent the overcoming of a phase of primary suppression in an individual who might otherwise have progressed toward lepromatous leprosy. The implications of this hypothesis for the planning of a controlled trial of an anti-leprosy vaccine are discussed.
一名4岁男孩在卡介苗皮内接种约6个月后，经临床和组织学诊断为界线类偏结核样型麻风。其母亲报告称，接种疫苗2周后，手臂接种部位上方开始出现一处皮损，2个月后下巴又出现了第二处皮损。淋巴细胞转化试验对超声处理的麻风杆菌、卡介苗和结核菌素纯蛋白衍生物的反应与结核样型麻风感染一致。卡介苗皮内感染引发界线类偏结核样型麻风，可能意味着原本可能发展为瘤型麻风的个体克服了原发性抑制阶段。本文讨论了这一假说对麻风病疫苗对照试验规划的意义。
