Shenai J P, Jhaveri B M, Reynolds J W, Huston R K, Babson S G
Pediatrics. 1981 May;67(5):631-7.
Although a soy-based lactose-free infant formula is sometimes used for feeding very low-birth-weight infants, the nutritional adequacy of this diet has not been thoroughly investigated. This study used the metabolic balance technique to compare nutrient retention rates in 19 very low-birth-weight (less than 1,530 gm) infants fed either a soy-based formula or a conventional milk-based formula. Serum chemistries and anthropometric measurements were assessed serially. The soy isolate supplemented with methionine as the sole dietary protein appeared to be adequately utilized, and nitrogen retention rates comparable to fetal accretion rates could be achieved in soy-fed infants in the limited period of study. The absence of lactose in the diet of soy-fed infants did not interfere with calcium metabolism. However, phosphorus absorption was diminished with the feeding of soy formula, which resulted in relative hypophosphatemia. Although the soy-fed infants showed increased renal conservation of phosphorus during the study period, the lesser absorption may, over time, stress phosphorus homeostatic control mechanisms. It is concluded that routine use of soy formula without specific therapeutic indications is undesirable in feeding very low-birth-weight infants. Extended use of such a formulation needs to be monitored for potential adverse effects on skeletal mineralization.
虽然有时会使用以大豆为基础的无乳糖婴儿配方奶粉来喂养极低出生体重的婴儿，但这种饮食的营养充足性尚未得到充分研究。本研究采用代谢平衡技术，比较了19名极低出生体重（小于1530克）婴儿分别喂食以大豆为基础的配方奶粉或传统牛奶配方奶粉时的营养保留率。连续评估血清化学指标和人体测量数据。以补充蛋氨酸的大豆分离物作为唯一膳食蛋白质，似乎得到了充分利用，并且在有限的研究期间，喂食大豆配方奶粉的婴儿能够实现与胎儿生长速率相当的氮保留率。喂食大豆配方奶粉的婴儿饮食中不含乳糖，这并未干扰钙代谢。然而，喂食大豆配方奶粉会降低磷的吸收，导致相对低磷血症。虽然在研究期间，喂食大豆配方奶粉的婴儿显示出肾脏对磷的保留增加，但随着时间的推移，较少的吸收可能会给磷稳态控制机制带来压力。得出的结论是，在喂养极低出生体重婴儿时，无特定治疗指征而常规使用大豆配方奶粉是不可取的。需要监测长期使用这种配方奶粉对骨骼矿化的潜在不良影响。
