帕吉林对急性和慢性乙醇处理大鼠肝脏谷胱甘肽水平的影响。
Effect of pargyline on hepatic glutathione levels in rats treated acutely and chronically with ethanol.
作者信息
Kaplan E, DeMaster E G, Nagasawa H T
出版信息
Res Commun Chem Pathol Pharmacol. 1980 Dec;30(3):577-80.
PMID:7196065
Abstract
A single dose of pargyline severely depleted hepatic reduced glutathione (GSH) levels in the rat. Ethanol administration, acute or chronic, had no effect on hepatic GSH levels; nor did such administration exacerbate the pargyline mediated GSH depletion. However a single dose of ethanol given one hour after pargyline administration enhanced the rate of recovery of hepatic GSH.
摘要
单剂量的优降宁会严重降低大鼠肝脏中还原型谷胱甘肽（GSH）的水平。急性或慢性给予乙醇对肝脏GSH水平没有影响；这种给药方式也不会加剧优降宁介导的GSH耗竭。然而，在给予优降宁一小时后给予单剂量乙醇可提高肝脏GSH的恢复速率。
Zotero 插件