免疫抑制剂硫唑嘌呤对四氧嘧啶诱导糖尿病的预防作用
The prevention of alloxan-induced diabetes by the immunosuppressive agent azathioprine.
作者信息
Heikkila R E, Cabbat F S
出版信息
Res Commun Chem Pathol Pharmacol. 1981 Jan;31(1):163-71.
PMID:7196067
Abstract
Azathioprine (1mmole/kg), given to male Swiss-Webster mice one hour prior to 75 mg/kg alloxan, was able to protect against the diabetogenic actions of alloxan. Various potential mechanisms for the protective effects of azathioprine, including its scavenging of the hydroxyl radical, which can be generated from alloxan, will be discussed.
摘要
在给雄性瑞士-韦伯斯特小鼠注射75毫克/千克四氧嘧啶前一小时，给予其硫唑嘌呤（1毫摩尔/千克），能够预防四氧嘧啶的致糖尿病作用。将讨论硫唑嘌呤产生保护作用的各种潜在机制，包括其对可由四氧嘧啶生成的羟基自由基的清除作用。
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