二甲基亚砜对小鼠四氧嘧啶诱导糖尿病的预防作用
The prevention of alloxan-induced diabetes in mice by dimethyl sulfoxide.
作者信息
Heikkila R E
出版信息
Eur J Pharmacol. 1977 Jul 15;44(2):191-3. doi: 10.1016/0014-2999(77)90106-6.
PMID:885168
Abstract
Dimethyl sulfoxide (DMSO, 7.3 g/kg) administered to mice prior to alloxan completely protected against the diabetogenic actions of 50 mg/kg alloxan. The same dose of DMSO provided a partial protection against 75 mg/kg alloxan. This protection against alloxan-induced diabetes is consistent with the scavenging of the hydroxyl radical by DMSO.
摘要
在给小鼠注射四氧嘧啶之前给予二甲基亚砜（DMSO，7.3克/千克），可完全保护小鼠免受50毫克/千克四氧嘧啶的致糖尿病作用。相同剂量的DMSO对75毫克/千克四氧嘧啶提供了部分保护。这种对四氧嘧啶诱导的糖尿病的保护作用与DMSO清除羟基自由基的作用一致。
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