Díaz N M, Moya M, Martín A, Doménech E
An Esp Pediatr. 1981 Feb;14(2):97-106.
Forty-one sample of adipose tissue were obtained by needle biopsy from thirty-two newborn at term and nine infants between two and 12 months. Number of fat cells of the newborn with birth-weights appropriate, large and low for their gestational age were similar (6-7 X 10(9). The babies whose birth weights were large for their gestational age showed a significant increase (p less than 0.001) in size of the fat cells (m + SD = 71.3 +/- 7.9), compared with those of low birth weight and control samples: 41.2 +/- 3.6 and 55.6 +/- 3.9 micrometer respectively. Percentage of body fat increases from a mean figure of 13.8% at birth to 24.9% at three months, in babies of normal weight. Growth of fat deposits is due to an increase in the size of adipose cells, reaching a mean value of 85.2 micrometer, without differences in number of fat cells present at birth. In the newborn as in infants diameter of fat cells has an important and positive correlation with the body weight and fat quantity. The same type of relationship exists between infants age and diameter of fat cells (r = 0.93). Four obese infants studied showed an increase in size of fat cells (m + SD = 112.7 +/- 10.9 micrometer) without modification in number of cells.
通过针吸活检从32名足月新生儿和9名2至12个月大的婴儿身上获取了41份脂肪组织样本。出生体重与其胎龄相称、较大和较低的新生儿的脂肪细胞数量相似（6 - 7×10⁹）。与低出生体重儿和对照样本相比，出生体重高于其胎龄的婴儿脂肪细胞大小显著增加（p < 0.001）（均值±标准差 = 71.3±7.9），低出生体重儿和对照样本的脂肪细胞大小分别为41.2±3.6和55.6±3.9微米。正常体重婴儿的体脂百分比从出生时的平均13.8%增加到三个月时的24.9%。脂肪沉积的增长是由于脂肪细胞大小增加，达到平均85.2微米，出生时存在的脂肪细胞数量没有差异。在新生儿和婴儿中，脂肪细胞直径与体重和脂肪量呈重要的正相关。婴儿年龄与脂肪细胞直径之间也存在相同类型的关系（r = 0.93）。研究的4名肥胖婴儿脂肪细胞大小增加（均值±标准差 = 112.7±10.9微米），细胞数量没有改变。
