Lynch C B
Genetics. 1980 Nov;96(3):757-65. doi: 10.1093/genetics/96.3.757.
Replicated bidirectional selection (with control lines) for nest-building behavior in Mus musculus, where nesting scores consisted of the total weight of cotton pulled through the cage lid during four days of testing, yielded an eight-fold difference between high and low lines after 15 generations of selection. The overall realized heritability pooled across lines and replicates was 0.18 +/- 0.02 (0.15 +/- 0.03 for high nesting scores and 0.23 +/- 0.04 for low nesting scores), or 0.28 +/- 0.05 when adjusted for within-family selection. Across the 15 generations and the entire experiment, average body weight and number of infertile matings increased, while average litter size decreased, although these changes were not consistent across lines. Inbreeding could account for average decreases in the fertility traits, but there was also a correlated response to selection, since both high lines showed increased litter size and decreased infertile matings.
对小家鼠筑巢行为进行了重复双向选择（设有对照品系），筑巢得分由测试四天期间穿过笼盖的棉花总重量组成，经过15代选择后，高选系和低选系之间产生了八倍的差异。跨品系和重复实验汇总的总体实现遗传力为0.18±0.02（高筑巢得分品系为0.15±0.03，低筑巢得分品系为0.23±0.04），经家系内选择调整后为0.28±0.05。在整个15代及整个实验过程中，平均体重和不育交配次数增加，而平均窝仔数减少，尽管这些变化在各品系间并不一致。近亲繁殖可能导致繁殖性状平均下降，但也存在对选择的相关反应，因为两个高选系均显示窝仔数增加且不育交配次数减少。
