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浅表性膀胱癌的复发频率和肿瘤进展(作者译)

[Frequency of recurrences and tumor progression on superficial bladder carcinoma (author's transl)].

作者信息

Rübben H, Dahm H H, Lutzeyer W

出版信息

Urologe A. 1981 Jul;20(4):211-4.

PMID:7196631
Abstract

A retrospective study with an adequate follow-up of three years or longer of 315 superficial transitional cell carcinomas (Ta--T2) is reported. Patients had transurethral resection in 80% and open excision or resection in 20% for cure or control. It is demonstrated, that in addition to the grade and the stage of the tumor, multifocal tumor growth and whether it is a primary or recurrent tumor influence the frequency of recurrences and the tumor progression. The overall percentage of recurrences after resection of Ta, T1 and T2 tumors within three years is 60%. A primary tumor recurs in 45%, the first recurrence in 84%, solitary tumors in 46% and multifocal tumors in 73%. Tumor progression is observed in solitary tumors in 24%, in multifocal tumors in 44%, in primary and recurrent Ta and primary T1 tumors in 20 to 25%, in recurrent T1 tumors in 56%. Therefore, when planning therapy, stage, grade, multifocal tumor growth and whether it is a primary or recurrent tumor should be considered. Ta tumors can be treated sufficiently by transurethral resection, even in case of several recurrences; more aggressive therapy should be considered, when multifocal or recurrent T1 or T2 tumors recur again as invasive carcinomas.

摘要

本文报道了一项回顾性研究,对315例浅表性移行细胞癌(Ta-T2)进行了为期三年或更长时间的充分随访。80%的患者接受了经尿道切除术,20%的患者接受了开放性切除或切除术以达到治愈或控制目的。结果表明,除了肿瘤的分级和分期外,多灶性肿瘤生长以及肿瘤是原发性还是复发性均会影响复发频率和肿瘤进展。Ta、T1和T2肿瘤切除术后三年内的总体复发率为60%。原发性肿瘤的复发率为45%,首次复发率为84%,孤立性肿瘤的复发率为46%,多灶性肿瘤的复发率为73%。孤立性肿瘤的肿瘤进展率为24%,多灶性肿瘤为44%,原发性和复发性Ta及原发性T1肿瘤为20%至25%,复发性T1肿瘤为56%。因此,在制定治疗方案时,应考虑肿瘤分期、分级、多灶性肿瘤生长以及肿瘤是原发性还是复发性。Ta肿瘤即使多次复发,经尿道切除术也可充分治疗;当多灶性或复发性T1或T2肿瘤再次复发为浸润性癌时,则应考虑更积极的治疗。

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