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用于双极电凝的调控高频透热疗法——一种治疗膀胱癌的新方法。

Regulated high frequency diathermy for bipolar electrocoagulation--a new method for the treatment of carcinoma of the bladder.

作者信息

Kriegmair M, Pensel J, Hofstetter A G, Fastenmeier K, Rothenberger K H, Keiditsch E, Boemers T M

机构信息

Department of Urology, University of Lübeck, Federal Republic of Germany.

出版信息

Urol Res. 1987;15(5):251-3. doi: 10.1007/BF00258190.

Abstract

In the endoscopic treatment of bladder cancer, especially for stages beyond T2, transurethral resection does not seem to be sufficient. The risk of bladder wall perforation, the possibility of incomplete resection, seeding of tumor cells and high recurrence rates support the former statement [6]. Results of a multicentre prospective randomised study have exemplified that irradiation with the Neodymium-YAG Laser has been a reasonable alternative in the therapeutic approach to bladder cancer [2]. Diathermy coagulation must produce a sufficiently deep, homogeneous and well demarcated tissue necrosis. The coagulation depth has to be adjustable and heat production during coagulation should not lead to bladder wall perforation and consequent damage to the bowel. These criteria were investigated using regulated bipolar high frequency diathermy. The innovation in this method is, that thermal side effects on the tissue, e.g. vaporisation and carbonisation are prevented by a protective relay with constant current flow. Animal experimental studies have shown that this method meets all postulated requirements and therefore clinical trials can proceed.

摘要

在内镜治疗膀胱癌时,尤其是对于T2期以上的患者,经尿道切除术似乎并不充分。膀胱壁穿孔的风险、不完全切除的可能性、肿瘤细胞种植以及高复发率都支持上述观点[6]。一项多中心前瞻性随机研究的结果表明,钕钇铝石榴石激光照射已成为膀胱癌治疗方法中的一种合理替代方案[2]。透热凝固必须产生足够深、均匀且界限清晰的组织坏死。凝固深度必须可调,并且凝固过程中的产热不应导致膀胱壁穿孔及随后的肠道损伤。使用可控双极高频透热对这些标准进行了研究。该方法的创新之处在于,通过具有恒定电流的保护继电器可防止对组织产生热副作用,如汽化和碳化。动物实验研究表明,该方法满足所有假定要求,因此可以进行临床试验。

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