Jones R M, Nahrwold M L, de Rosayro A M, Hill A B
Anesth Analg. 1981 Sep;60(9):641-5.
In four patients, infusion of a hyperosmolar solution of urea to decrease brain volume was associated with hypotension and a decreasing of plasma levels of ionized calcium. This prompted a further study into the effects of intravenous hyperosmolar urea solutions on cardiovascular function and plasma levels of cations in the anesthetized dog. Using an infusion rate of 250 mg/kg/min, significant (p less than 0.05) reductions in mean arterial pressure, systemic vascular resistance, hematocrit, and levels of plasma sodium and ionized calcium were found. These changes were associated with significant (p less than 0.05) increases in cardiac output, right atrial pressure, arterial PO2 and PCO2, and levels of plasma potassium. It is concluded that rapid infusions of hyperosmolar urea may have important effects of hemodynamic status and plasma cation concentrations.
在4例患者中，输注高渗尿素溶液以减少脑容量与低血压及血浆离子钙水平降低有关。这促使对麻醉犬静脉输注高渗尿素溶液对心血管功能和血浆阳离子水平的影响进行进一步研究。以250mg/kg/min的输注速率进行输注时，发现平均动脉压、全身血管阻力、血细胞比容以及血浆钠和离子钙水平显著（p<0.05）降低。这些变化与心输出量、右心房压力、动脉血氧分压和二氧化碳分压以及血浆钾水平显著（p<0.05）升高有关。结论是快速输注高渗尿素可能对血流动力学状态和血浆阳离子浓度有重要影响。
