Fritz H, Becker H
Arzneimittelforschung. 1981;31(5):813-5.
The 2% aqueous solution of a sodium carboxymethylcellulose (CMC) was administered by gavage to 20 male and 40 female albino rats at the daily volume of 1 ml/100 g body weight. The males were treated for at least 60 days and the females for at least 14 days prior to mating and during a 6-day mating period. In one half of the females treatment was continued until sacrifice on day 14 of pregnancy; in the other half of the female treatment was continued until weaning of the progeny. A variety of tests was used to examine the behavioural performance of the pups. The overall results of this study were comparable for both test groups, CMC treated and untreated. Consequently, the CMC used here is considered to be a suitable vehicle for suspending tests materials for oral administration in long-term reproductive studies in rats.
将羧甲基纤维素钠（CMC）的2%水溶液以1 ml/100 g体重的日剂量通过灌胃给予20只雄性和40只雌性白化大鼠。雄性大鼠在交配前至少治疗60天，雌性大鼠在交配前至少治疗14天，并在6天的交配期内持续治疗。在一半的雌性大鼠中，治疗持续到怀孕第14天处死；在另一半雌性大鼠中，治疗持续到后代断奶。使用了各种测试来检查幼崽的行为表现。该研究的总体结果在CMC处理组和未处理组这两个测试组中具有可比性。因此，这里使用的CMC被认为是在大鼠长期生殖研究中用于悬浮口服给药测试材料的合适载体。
