Sheldrake F E, Webber J M, Marsh B D
Curr Med Res Opin. 1977;5(1):106-16. doi: 10.1185/03007997709108986.
A multi-centre open study of flurbiprofen was started in 1971 to provide regular clinical and laboratory data on patients with a variety of arthritic conditions. To date, 1220 patients have received the drug in a dosage varying from 75 mg to 400 mg daily. Flurbiprofen has been shown to be effective in relieving symptoms in the degenerative and inflammatory arthritides and side-effects have not proved a problem. Patients aged 65 years and over appear to tolerate the drug as well as their younger counterparts, an important finding in a group of patients notoriously intolerant of many drugs.
1971年开始了一项关于氟比洛芬的多中心开放性研究,旨在获取各类关节炎患者的常规临床和实验室数据。迄今为止,1220名患者接受了该药物治疗,日剂量从75毫克到400毫克不等。已证明氟比洛芬在缓解退行性和炎症性关节炎症状方面有效,且副作用不成问题。65岁及以上的患者似乎与年轻患者一样能耐受该药物,这在一群众所周知对许多药物耐受性差的患者中是一项重要发现。