Halsey J P, Cardoe N
Br Med J (Clin Res Ed). 1982 May 8;284(6326):1365-8. doi: 10.1136/bmj.284.6326.1365.
Out of 300 patients who had taken benoxaprofen for a mean of 6.4 months, 196 (65.3%) reported side effects, resulting in 104 patients (34.6%) having the drug withdrawn. Out of 42 patients aged over 70, 35 (83.3%) had side effects and 29 (69.0%) had the drug withdrawn because of them. cutaneous side effects accounted for 180 (69.5%) of all 259 side effects reported. The commonest cutaneous side effect was photosensitivity, which occurred in 86 patients (28.6%). Photosensitivity, which occurred in half of the patients treated in the summer, resulted in withdrawal of benoxaprofen in 26 (30.2%) of the patients who experienced it. Onycholysis was observed in 38 patients (12.6%) and was frequently unnoticed by patients. The overall incidence of gastric side effects was 12.6% (38 patients), and the figure rose to 40.5% (17 cases) in patients over 70. During treatment with benoxaprofen one patient developed an active duodenal ulcer but no cases of major gastrointestinal haemorrhage occurred. Multiple subepidermal cysts (milia) were observed in 16 patients, who had been treated for a mean of 10.8 months. These findings show that benoxaprofen is a potent phototoxic drug and that the manufacturers' recommended dosage of 600 mg daily is associated with an unacceptable incidence of side effects in the elderly.
在300名平均服用贝诺洛芬6.4个月的患者中，196名（65.3%）报告有副作用，导致104名患者（34.6%）停药。在42名70岁以上的患者中，35名（83.3%）有副作用，其中29名（69.0%）因副作用停药。皮肤副作用占所有259例报告副作用的180例（69.5%）。最常见的皮肤副作用是光敏性，86名患者（28.6%）出现此症状。光敏性在夏季接受治疗的患者中半数出现，导致26名（30.2%）出现该症状的患者停用贝诺洛芬。38名患者（12.6%）出现甲床分离，患者往往未注意到。胃部副作用的总体发生率为12.6%（38例患者），70岁以上患者中这一数字升至40.5%（17例）。在使用贝诺洛芬治疗期间，有1名患者出现活动性十二指肠溃疡，但未发生重大胃肠道出血病例。16名患者观察到多发性表皮下囊肿（粟丘疹），这些患者平均接受治疗10.8个月。这些发现表明，贝诺洛芬是一种强效光毒性药物，制造商推荐的每日600毫克剂量与老年人不可接受的副作用发生率相关。
