Chalon J, Tang C K, Ramanathan S, Eisner M, Katz R, Turndorf H
Anesth Analg. 1981 Nov;60(11):794-7.
This study was conducted to assess the learning function of murine progeny born of mothers that had received either 1% or 2% halothane or 2% or 4% enflurane, on days 6 and 10 or days 14 and 17 or gestation. Their timed performance at the age of 6 to 7 weeks was compared in a maze with that of control mice of similar ages that had not been exposed to anesthetics prenatally. All mice exposed to halothane in utero performed poorly at first, especially the group with mothers exposed to 2% halothane on days 14 and 17 of pregnancy. By the 10th training period, the performance of all mice improved but remained significantly slower than control mice. The offsprings of mice exposed to enflurane also performed poorly on the first training period, but between the fifth and seventh training periods, made statistically significant progress. However, they too remained slower in maze performance than control mice. Although blood pressure and arterial blood gas studies were only performed on two pregnant mice, data obtained suggest that the anesthetics did not have sufficient effect on respiration to affect our results. Second generation offspring, born to dams exposed to 2% halothane in utero late in pregnancy and sired by normal unexposed males, were also consistently slower than control mice, indicating a possible genetic effect induced by the anesthetic.
本研究旨在评估在妊娠第6天和第10天或第14天和第17天接受1%或2%氟烷或2%或4%恩氟烷的母鼠所产后代的学习功能。将6至7周龄时它们在迷宫中的定时表现与未在产前接触过麻醉剂的同龄对照小鼠进行比较。所有在子宫内接触氟烷的小鼠起初表现不佳，尤其是母亲在妊娠第14天和第17天接触2%氟烷的组。到第10个训练期时，所有小鼠的表现都有所改善，但仍明显慢于对照小鼠。接触恩氟烷的小鼠后代在第一个训练期也表现不佳，但在第五个和第七个训练期之间取得了统计学上的显著进步。然而，它们在迷宫表现上也仍然比对照小鼠慢。尽管仅对两只怀孕小鼠进行了血压和动脉血气研究，但获得的数据表明，麻醉剂对呼吸的影响不足以影响我们的结果。由在妊娠后期子宫内接触2%氟烷的母鼠所产并由未接触过麻醉剂的正常雄鼠所生的第二代后代，也始终比对照小鼠慢，这表明麻醉剂可能诱导了遗传效应。
