Hiraoka T, Kambara T, Morinaga T, Nakagawa S
Acta Pathol Jpn. 1981 Sep;31(5):853-61. doi: 10.1111/j.1440-1827.1981.tb02810.x.
An autopsy case of hemangioendothelial sarcoma of the liver which occurred 33 years after the injection of thorotrast was reported. A fifty-nine years old male with complaint of abdominal swelling and progressive jaundice died of hepatic failure and hemorrhage from gastric ulcer after 10 days of medical treatment in the Kumamoto University Hospital. Autopsy revealed hemangioendothelial sarcoma and multiple capillary hemangiomas in the liver. Histologically, a yellowish brown crystalline substance was intensively accumulated in the connective tissue in and adjacent to the thickened capsule of the liver, the lymph nodes of hepatic hilus, the spleen, the bone and the bone marrow. The material was certified as thorotrast with the Th-232 activity measurement and the autoradiographical examination. The absorbed dose of irradiation of the local liver tissue was calculated to be approximately 2,597 rads in 33 years. The relation among capillary hemangioma, hemangioendothelial sarcoma, and thorotrast was discussed.
报告了一例注射钍造影剂33年后发生的肝脏血管内皮肉瘤尸检病例。一名59岁男性，因腹胀和进行性黄疸入院，在熊本大学医院接受治疗10天后，死于肝衰竭和胃溃疡出血。尸检发现肝脏中有血管内皮肉瘤和多发性毛细血管瘤。组织学检查显示，一种黄褐色结晶物质大量积聚在肝脏增厚包膜内及邻近的结缔组织、肝门淋巴结、脾脏、骨骼和骨髓中。通过钍-232活性测量和放射自显影检查，证实该物质为钍造影剂。据计算，局部肝组织在33年中的吸收辐射剂量约为2597拉德。讨论了毛细血管瘤、血管内皮肉瘤与钍造影剂之间的关系。
