以胃电位差为模型比较胆茶碱与茶碱的胃刺激性。
Comparison of choline theophyllinate and theophylline gastric irritation utilizing gastric potential difference as a model.
作者信息
Kraus M, Lücker P W, Eldon M A
出版信息
Arzneimittelforschung. 1981;31(9):1503-7.
PMID:7197964
Abstract
Choline theophyllinate and theophylline were administered to 14 healthy volunteers following which the irritant effects of each drug were determined by measuring changes in gastric potential difference (GPD). Theophylline was found to be 2 and 3 times more irritating than choline theophyllinate in terms of mean membrane instability time and mean irritation index parameters, respectively. Considerations after the study indicated that the crossover design utilized was an efficient study design for the GPD model.
摘要
对14名健康志愿者给予胆茶碱和茶碱，随后通过测量胃电位差（GPD）的变化来确定每种药物的刺激作用。就平均膜不稳定时间和平均刺激指数参数而言，发现茶碱的刺激性分别是胆茶碱的2倍和3倍。研究后的考虑表明，所采用的交叉设计对于GPD模型来说是一种有效的研究设计。
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