The action of S-adenosyl-L-methionine on the levels of triglyceride and phospholipid precursors in ethanol-intoxicated rat liver.

Acute ethanol intoxication (7 g/kg body wt) produces modifications of rat liver lipid metabolism. The effect of S-adenosyl-L-methionine (SAM) on hepatic triglyceride accumulation and on some hydrosoluble phospholipid precursors (phosphorylcholine, phosphorylethanolamine, CDP-choline, CDP-ethanolamine) has been examined in this work. The administration of SAM improves the removal of triacylglycerol from ethanol-intoxicated livers and produces modifications of the pools of some hydrosoluble phospholipid precursors.