Losonsky G A, Ogra P L
Prog Clin Biol Res. 1981;70:171-82.
The mammary glands are a uniquely designed extension of the mucosal immune systems of the gut and bronchus. The soluble and cellular products of lactation, in which immunologic selectivity and specificity exist, link the suckling neonate irrevocably to the immunologic and infectious experience of its mother. The immune competence of the breast and products of lactation are actively and constantly in flux, dependent on the mother's hormonal, environmental, and immunologic milieu. Most of the recent human investigation has focused primarily on milk immunoglobulin specificity. More work needs to be done on the role of passively transferred cellular products, the antiviral, antiprotozoan, and antitumor capabilities of milk, and on the mechanisms by which maternal immunizations or infections may influence the outcome of host-pathogen interactions in the suckling neonate.
乳腺是肠道和支气管黏膜免疫系统独特设计的延伸。乳汁中的可溶性和细胞性产物具有免疫选择性和特异性，将哺乳的新生儿与母亲的免疫和感染经历不可逆转地联系在一起。乳腺的免疫能力和乳汁产物处于活跃且不断变化的状态，这取决于母亲的激素、环境和免疫环境。最近大多数人体研究主要集中在乳汁免疫球蛋白的特异性上。关于被动转移的细胞产物的作用、乳汁的抗病毒、抗原生动物和抗肿瘤能力，以及母体免疫或感染可能影响哺乳新生儿宿主-病原体相互作用结果的机制，还需要开展更多研究。
