Gurpegui M, Monge A, Fuentes J A
Arzneimittelforschung. 1981;31(10):1710-2.
The first indole-hydrazide, 1-[2,-(3-methyl)-5-benzyloxyindolyl]carbonyl-2-isopropyl hydrazide (IH-3), that irreversibly inhibits mouse brain type A monoamine oxidase is measured by 5-hydroxytryptamine deamination. The concentration required in vitro to inhibit this isoenzyme is about 7 X 10(-8) mol/l. Other biochemical and pharmacological features of this potential antidepressant are presented.
首个不可逆抑制小鼠脑A型单胺氧化酶的吲哚酰肼，即1-[2,-(3-甲基)-5-苄氧基吲哚基]羰基-2-异丙基肼(IH-3)，通过5-羟色胺脱氨作用进行测定。体外抑制这种同工酶所需的浓度约为7×10(-8)摩尔/升。文中还介绍了这种潜在抗抑郁药的其他生化和药理学特性。
