Antoshchina M M, Poriadkova N A, Luchnik N V
Genetika. 1981;17(12):2167-71.
Chinese hamster cells and human lymphocytes were incubated with BrdUrd during two cycles of replication and stained using the "harlequine" technique. The G2 cells were irradiated with 1 Gy of gamma-rays from the 60 Co source. The frequency of breaks in light (i.e. bifiliary substituted) chromatids was significantly lower, as compared with dark (i.e. unifiliary substituted) ones. The comparison of these data with the previously published suggests that the relative frequency of breaks in uni- and bifiliary substituted chromatids depends on the energy of quanta. A hypothesis is discussed that a resonance absorption of energy by Br atoms and an increased interaction between BrdUrd-substituted structures, which favours the repair of double-strand breaks, can explain the noted regularity.
将中国仓鼠细胞和人类淋巴细胞在两个复制周期中与溴脱氧尿苷（BrdUrd）一起孵育，并使用“哈勒奎因”技术进行染色。用来自60钴源的1 Gyγ射线照射G2期细胞。与深色（即单链取代）染色单体相比，浅色（即双链取代）染色单体中的断裂频率显著更低。将这些数据与先前发表的数据进行比较表明，单链和双链取代染色单体中断裂的相对频率取决于量子能量。讨论了一种假说，即溴原子对能量的共振吸收以及BrdUrd取代结构之间增强的相互作用有利于双链断裂的修复，这可以解释上述规律。
