关于曲酸胺存在类似γ-氨基丁酸作用的进一步证据。

Further evidence for a GABA-like action on kojic amine.

作者信息

Martin G E, Bendesky R J

出版信息

Neurosci Lett. 1981 Nov 18;27(1):37-40. doi: 10.1016/0304-3940(81)90202-0.

PMID:7199127

Abstract

Data are reported to support the hypothesis that kojic amine is a GABA agonist in an in vivo model of GABAergic activity. The unilateral intranigral microinjection of kojic amine elicited dose-related turning contraversive from the injection site. The direction of the turning is identical to that observed after the intranigral administration of muscimol or other GABA agonists. Furthermore, the numbers of turns elicited by kojic amine was significantly reduced following pretreatment with the GABA antagonist, bicuculline. The results suggest that kojic amine is a GABA agonist.

摘要

有数据报告支持这样的假设，即在体内γ-氨基丁酸能活性模型中，曲酸胺是一种γ-氨基丁酸（GABA）激动剂。单侧黑质内微量注射曲酸胺会引发与剂量相关的向注射部位对侧的旋转。旋转方向与黑质内注射蝇蕈醇或其他GABA激动剂后观察到的方向相同。此外，用GABA拮抗剂荷包牡丹碱预处理后，曲酸胺引发的旋转次数显著减少。结果表明，曲酸胺是一种GABA激动剂。