Tang M, Brown C, Falk J L
Pharmacol Biochem Behav. 1982 Jan;16(1):155-8. doi: 10.1016/0091-3057(82)90028-4.
Rats exposed to daily 3-hr intermittent food delivery sessions (binging) chronically ingested excessive amounts of either H2O or 5% EtOH (mean 7.1 g/kg/3-hr). Withdrawing the intermittency of the feeding schedule once every 10 days (single-ration probe session) resulted in reduction of fluid intakes (both H2O and EtOH) to the level of animals always given daily single-ration sessions. This complete dependence of elevated fluid intake levels on the intermittent feeding schedule was unaffected by either the number of probes previously administered (0 to 11) or the duration the feeding schedule was maintained before introduction of the first probe session (29 or 109 days). The results of the probe sessions demonstrated that a history of ethanol overindulgence was not a sufficient condition for the maintenance of overdrinking. Continued overindulgence required the continued presence of the original inducing conditions. Ethanol-polydipsic animals exposed to periodic probe sessions also developed a slow rise in binge session intake. No such increase was observed in the water-polydipsic animals.
每天暴露于3小时间歇性食物供应时段（暴饮暴食）的大鼠长期摄入过量的水或5%乙醇（平均7.1克/千克/3小时）。每10天中断一次喂食计划（单次定量探测时段）会导致液体摄入量（水和乙醇）降至每天给予单次定量喂食的动物水平。液体摄入量升高对间歇性喂食计划的这种完全依赖性不受先前给予的探测次数（0至11次）或在引入第一次探测时段之前维持喂食计划的持续时间（29天或109天）的影响。探测时段的结果表明，乙醇过度放纵的历史不是维持过度饮水的充分条件。持续的过度放纵需要原始诱导条件的持续存在。暴露于周期性探测时段的乙醇多饮动物在暴饮暴食时段的摄入量也出现缓慢上升。在水多饮动物中未观察到这种增加。
