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在经历不同昼夜分布的诱导程序训练的大鼠中,长期饮酒及随后的戒断情况。

Chronic alcohol drinking and subsequent withdrawal in rats exposed to different diurnal distributions of schedule-induction sessions.

作者信息

Gilbert R M

出版信息

Adv Exp Med Biol. 1977;85B:503-22. doi: 10.1007/978-1-4615-9038-5_32.

DOI:10.1007/978-1-4615-9038-5_32
PMID:563667
Abstract

Eight rats drank large amounts of 6.25% alcohol as a consequence of daily exposure to 6 hours of schedule-induction sessions in which a small food pellet was delivered every 90 sec. Rats having a 1-hr session every 4 hr showed slightly more withdrawal distress than rats having a 6-hr session every 24 hr. More significant may have been two different kinds of indication of possible loss of control over drinking by the inducing schedule. Rats experiencing six sessions a day did not drink water excessively when it replaced the alcohol solution. Rats experiencing one session a day drank half their total alcohol intake between sessions. If the schedule-induction procedure loses control over alcohol drinking, its chronic application to animals fails as a model of the factors that maintain excessive alcohol use in humans.

摘要

八只大鼠由于每天暴露于6小时的诱导程序中,大量饮用6.25%的酒精,在该诱导程序中,每90秒投放一粒小食物颗粒。每4小时进行1小时实验的大鼠比每24小时进行6小时实验的大鼠表现出略多的戒断痛苦。诱导程序可能导致饮酒失控的两种不同迹象或许更为显著。每天经历六次实验的大鼠在酒精溶液被水替代时不会过度饮水。每天经历一次实验的大鼠在两次实验之间喝掉了其总酒精摄入量的一半。如果诱导程序失去了对饮酒的控制,那么将其长期应用于动物就无法作为维持人类过度饮酒因素的模型。

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