哮喘中的夜间咳嗽。
Nocturnal cough in asthma.
作者信息
Thomson A H, Pratt C, Simpson H
机构信息
Department of Child Health, University of Leicester.
出版信息
Arch Dis Child. 1987 Oct;62(10):1001-4. doi: 10.1136/adc.62.10.1001.
The timing of nocturnal cough and its association with change in ambient temperature was documented in 11 asthmatic children, median age 5.1 years, while they were receiving continuous prophylaxis. Studies were performed in their homes on three nights. A voice activated system with electronic time signal recorded coughing. Ambient temperature was recorded every five minutes throughout the night on a Grant Squirrel data logger. Ten children coughed on 27 nights with a median of six bouts of coughing a night (range 0-272). The cough rate in the two hours after going to bed was significantly higher than the cough rate in the middle of the night (2-4 am or 4-6 am). Peak coughing times were 7-9 pm and 6-8 am. The room temperature was lowest between 5 and 7 am. There were no significant differences between cough rates during periods of rapid temperature change (more than 1 degree C an hour). The timing of nocturnal cough observed in this study differed from the known basophase of circadian cycles described for adults and children.
在11名哮喘儿童（中位年龄5.1岁）接受持续预防治疗期间，记录了夜间咳嗽的时间及其与环境温度变化的关系。研究在他们家中进行了三个晚上。一个带有电子时间信号的声控系统记录咳嗽情况。整个晚上每隔五分钟用格兰特松鼠数据记录仪记录一次环境温度。10名儿童在27个晚上咳嗽，每晚咳嗽次数中位数为6次（范围0 - 272次）。上床睡觉后两小时内的咳嗽频率明显高于午夜（凌晨2 - 4点或4 - 6点）。咳嗽高峰时间为晚上7 - 9点和早上6 - 8点。室温在凌晨5点到7点之间最低。在温度快速变化期间（每小时超过1摄氏度），咳嗽频率没有显著差异。本研究中观察到的夜间咳嗽时间与已知的成人和儿童昼夜节律的基础阶段不同。
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