Mellanby J, Strawbridge P, Collingridge G I, George G, Rands G, Stroud C, Thompson P
J Neurol Neurosurg Psychiatry. 1981 Dec;44(12):1084-93. doi: 10.1136/jnnp.44.12.1084.
Experiments are reported describing assessment of abnormal behaviour of rats in which a chronic epileptiform syndrome has been induced by the injection of tetanus toxin bilaterally into their hippocampi. The abnormal behaviour included hyper-reactivity to a novel environment, intermittent aggression on handling, and abnormally passive response to a strange rat introduced into their home cage. In animals with unilateral injection of toxin, electrical records from the hippocampi have been obtained. They illustrated bilaterally simultaneous discharges and also some independence between the two hippocampi. The discharges were accompanied by overt signs of complex partial seizures during the first few weeks of the syndrome but later occurred without motor signs. In this later stage the rats were somewhat resistant to the convulsant effects of pentylenetetrazol.
报告了一些实验，这些实验描述了对大鼠异常行为的评估，其中通过双侧向其海马体注射破伤风毒素诱发了慢性癫痫样综合征。异常行为包括对新环境的过度反应、处理过程中的间歇性攻击以及对引入其笼舍的陌生大鼠的异常被动反应。在单侧注射毒素的动物中，已获取了海马体的电记录。这些记录显示了双侧同时放电，并且两个海马体之间也存在一定的独立性。在综合征的最初几周，放电伴有复杂部分性发作的明显迹象，但后来发作时没有运动迹象。在这个后期阶段，大鼠对戊四氮的惊厥作用有一定抵抗力。
