Fariello R G, Golden G T, Pisa M
Neurology. 1982 Mar;32(3):241-5. doi: 10.1212/wnl.32.3.241.
Pretreatment of rats with homotaurine (3 aminopropanesulfonic acid; 3APS), a synthetic gamma-aminobutyric acid (GABA) analog, protected from the convulsant and cytotoxic action of systemically injected kainic acid (KA). Wet dog shaking (WDS) behavior was significantly reduced. Taurine, an inhibitory non-GABA-mimetic amino acid, and muscimol (another direct GABA-agonist) reduced the number of seizures and lesions in the brain but were less effective than homotaurine. Progabide (a GABA-agonist) did not modify kainic acid effects. The neurotoxicity of kainic acid could have been due to repetitive convulsive activity. Activation of GABA-mediated inhibition is an effective, but not the determinant means of preventing KA-induced abnormalities.
用高牛磺酸（3-氨基丙烷磺酸；3APS）对大鼠进行预处理，3APS是一种合成的γ-氨基丁酸（GABA）类似物，可保护大鼠免受全身注射海藻酸（KA）的惊厥和细胞毒性作用。湿狗样抖动（WDS）行为显著减少。牛磺酸是一种抑制性非GABA模拟氨基酸，蝇蕈醇（另一种直接GABA激动剂）减少了癫痫发作次数和脑损伤，但效果不如高牛磺酸。普罗加比（一种GABA激动剂）并未改变海藻酸的作用。海藻酸的神经毒性可能是由于反复惊厥活动所致。GABA介导的抑制作用的激活是预防KA诱导异常的一种有效手段，但不是决定性手段。
