纳洛酮可阻断吗啡对 kainic 酸神经毒性的增强作用。

Naloxone blocks morphine enhancement of kainic acid neurotoxicity.

作者信息

Fuller T A, Olney J W, Conboy V T

出版信息

Life Sci. 1982 Jul 19;31(3):229-33. doi: 10.1016/0024-3205(82)90582-3.

Abstract

Kainic acid (KA) is a potent convulsant which, when administered subcutaneously, induces sustained limbic seizures and a pattern of limbic brain damage that is thought to be seizure-mediated. Diazepam suppresses and morphine enhances both the seizures and brain damage induced by KA. Here we show that morphine enhancement of KA neurotoxicity is blocked in a dose-dependent manner by subcutaneous pretreatment with naloxone. Theses and related findings support the hypothesis that morphine enhances the seizure-linked neurotoxicity of KA by an opiate specific action at certain limbic receptor sites where opiates suppress GABAergic activity, thereby lowering the threshold for propagation of seizure activity in limbic circuits.

摘要

海藻酸（KA）是一种强效惊厥剂，皮下注射时会诱发持续性边缘叶癫痫发作以及一种被认为由癫痫介导的边缘叶脑损伤模式。地西泮可抑制，而吗啡会增强KA诱发的癫痫发作和脑损伤。在此我们表明，皮下注射纳洛酮预处理能以剂量依赖的方式阻断吗啡对KA神经毒性的增强作用。这些以及相关发现支持了这样一种假说，即吗啡通过在某些边缘叶受体部位的阿片类特异性作用增强KA与癫痫发作相关的神经毒性，在这些部位阿片类药物抑制γ-氨基丁酸能活性，从而降低边缘叶回路中癫痫活动传播的阈值。