Sedman G L, Austin L, Langford C J
Neurosci Lett. 1982 Jan 22;28(1):93-9. doi: 10.1016/0304-3940(82)90214-2.
The chronic effect of ethanol on central nervous system protein turnover was investigated in selected regions of brain following intoxication and withdrawal in a strain of ethanol preferring mice. Mice were serially injected with [14C]glucose in order to achieve a constant specific radioactivity of brain glutamate. Protein turnover was calculated from the specific activities of extracted protein and free glutamate. Results from these studies show that ethanol causes a significant increase in protein turnover in all sections of brain. The brain protein turnover in animals following alcohol withdrawal also shows an increase which deviates significantly from controls in 2 of the 3 regions examined.
在一组偏爱乙醇的小鼠中毒和戒断后，研究了乙醇对大脑选定区域中枢神经系统蛋白质周转的慢性影响。为了使脑谷氨酸的比放射性恒定，给小鼠连续注射[14C]葡萄糖。根据提取的蛋白质和游离谷氨酸的比活性计算蛋白质周转率。这些研究结果表明，乙醇会导致大脑所有区域的蛋白质周转率显著增加。戒酒动物的脑蛋白质周转率也有所增加，在所检查的3个区域中有2个区域与对照组相比有显著差异。
