慢性酒精中毒患者的脑萎缩：一项病理学研究。
Brain shrinkage in chronic alcoholics: a pathological study.
作者信息
Harper C G, Kril J J, Holloway R L
出版信息
Br Med J (Clin Res Ed). 1985 Feb 16;290(6467):501-4. doi: 10.1136/bmj.290.6467.501.
Abstract
A quantitative neuropathological necropsy study of 22 control and 22 chronic alcoholic subjects showed a statistically significant loss of brain tissue in the chronic alcoholic group. The loss of tissue appeared to be from the white matter of the cerebral hemispheres rather than the cerebral cortex. This may reflect a primary alteration in the composition or structure of the white matter or it may be secondary to loss of nerve cells from the cortex with subsequent degeneration of the axons in the white matter. Further morphometric analyses including cortical neuronal counts will be necessary to clarify this issue.
摘要
一项针对22名对照者和22名慢性酒精中毒患者的定量神经病理学尸检研究表明，慢性酒精中毒组脑组织出现了具有统计学意义的损失。组织损失似乎来自大脑半球的白质而非大脑皮层。这可能反映了白质成分或结构的原发性改变，也可能是继发于皮层神经细胞的损失以及随后白质中轴突的退化。需要进一步进行包括皮层神经元计数在内的形态计量学分析来阐明这个问题。
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