Drake J J, Butterworth K R, Gaunt I F, Hooson J, Evans J G, Gangolli S D
Food Chem Toxicol. 1982 Feb;20(1):15-23. doi: 10.1016/s0278-6915(82)80004-5.
Groups of 48 male and 48 female rats were fed quillaia extract in the diet at levels of 0 (controls), 0.3, 1.0 and 3.0% for 2 yr. The material had no adverse effects on death rate, water consumption, serum chemistry or haematological parameters or on the incidence of histopathological findings, including tumours. In the males given the 3% dietary level, the death rate, total leucocyte count at wk 108, incidence of kidney lesions and weights of the kidneys, heart and thyroid were all below the control values. These differences were explicable, however, in terms of a lowered body weight consequent on a decreased food intake. It is concluded that, in rats, quillaia extract fed at levels up to 3.0% in the diet did not have any carcinogenic effect. The no-untoward-effect level established in this was 3.0% in the diet, approximately equivalent to an intake of 1.5 g/kg/day.
将48只雄性大鼠和48只雌性大鼠分为几组，在两年时间里，分别用含0（对照组）、0.3%、1.0%和3.0%皂树皮提取物的饲料喂养。该物质对死亡率、饮水量、血清化学指标、血液学参数或组织病理学检查结果（包括肿瘤）的发生率均无不良影响。在给予3%饲料水平的雄性大鼠中，死亡率、第108周时的白细胞总数、肾脏病变发生率以及肾脏、心脏和甲状腺的重量均低于对照值。然而，这些差异可以用食物摄入量减少导致体重降低来解释。得出的结论是，在大鼠中，饲料中皂树皮提取物含量高达3.0%时没有任何致癌作用。在此确定的无不良影响水平为饲料中3.0%，大约相当于摄入量为1.5克/千克/天。
