Ingram A J, Butterworth K R, Gaunt I F, Gangolli S D
Food Chem Toxicol. 1982 Jun;20(3):253-7.
Groups of rats were given metatartaric acid in the drinking-water in concentrations of 0 (control), 0.1, 0.5 or 3.0% for 18 wk. No effects associated with treatment were seen in the results of the haematological examinations and serum analyses. The treated animals consumed less water and food than the controls, probably because of the unpalatability of the test material. Administration of the 3% solution was associated in males with a reduced growth rate, some impairment of urine-concentrating ability during prolonged water deprivation (also seen in males on 0.5%) and histopathological changes in the stomach indicative of an inflammatory response in the submucosal layer. Both sexes of the 3% group showed an increase in relative kidney weight, without accompanying histopathological change. The no-untoward-effect level in this study was 0.1% metatartaric acid in the drinking-water, equivalent to a mean daily intake of 80 mg/kg body weight in the males and 130 mg/kg in the females.
将大鼠分成几组，让它们饮用浓度分别为0（对照组）、0.1%、0.5%或3.0%的偏酒石酸溶液，持续18周。血液学检查和血清分析结果未发现与治疗相关的影响。与对照组相比，接受治疗的动物饮水量和食量较少，这可能是因为受试材料味道不佳。给雄性大鼠施用3%的溶液会导致生长速率降低，在长时间缺水期间尿液浓缩能力出现一定损害（0.5%组的雄性大鼠也有此现象），并且胃部出现组织病理学变化，表明黏膜下层有炎症反应。3%组的雌雄大鼠肾脏相对重量均增加，但无相应的组织病理学变化。本研究中未观察到不良影响的水平为饮用水中偏酒石酸浓度0.1%，相当于雄性大鼠平均每日摄入量为80毫克/千克体重，雌性大鼠为130毫克/千克体重。
