Brüggen J, Fogh J, Sorg C
J Cancer Res Clin Oncol. 1981;102(2):141-52. doi: 10.1007/BF00410665.
It has been reported previously that antisera produced in non human primates against many cultured human melanoma lines recognize tumor-associated antigens on the melanoma cells. The reactivity correlated with other parameters of malignancy, such as rapidity of tumor growth in nude mice and release of plasminogen activator. In this study we have investigated whether these antisera also react with non melanoma cancer lines and searched for a correlation between this reaction and the other parameters of malignancy. There was cross-reactivity of the ten sera with 4-43% of the 46 non melanoma lines compared to 62-100% of the 16 melanoma lines, indicating a preferential reactivity with melanoma lines. For the non-melanoma lines no correlation was found between the release of plasminogen activator, the degree of tumorigenicity in the nude mouse or the reactivity of surface antigens as detected with antimelanoma sera.
先前已有报道称，在非人类灵长类动物中产生的针对许多培养的人类黑色素瘤细胞系的抗血清可识别黑色素瘤细胞上的肿瘤相关抗原。这种反应性与恶性肿瘤的其他参数相关，如裸鼠体内肿瘤生长的速度和纤溶酶原激活剂的释放。在本研究中，我们调查了这些抗血清是否也与非黑色素瘤癌细胞系发生反应，并寻找这种反应与恶性肿瘤其他参数之间的相关性。与16个黑色素瘤细胞系中的62%-100%相比，这10种血清与46个非黑色素瘤细胞系中的4%-43%存在交叉反应，表明对黑色素瘤细胞系具有优先反应性。对于非黑色素瘤细胞系，未发现纤溶酶原激活剂的释放、裸鼠体内的致瘤程度或用抗黑色素瘤血清检测的表面抗原反应性之间存在相关性。
