Siegel S, Hinson R E, Krank M D, McCully J
Science. 1982 Apr 23;216(4544):436-7. doi: 10.1126/science.7200260.
A model of "overdose" deaths among heroin addicts is proposed which emphasizes recent findings concerning the contribution of drug-associated environmental cues to drug tolerance. Results of animal experiments performed to evaluate this model suggest that conditioned drug-anticipatory responses, in addition to pharmacological factors, affect heroin-induced mortality.
本文提出了一种海洛因成瘾者“过量用药”死亡的模型，该模型强调了有关药物相关环境线索对药物耐受性影响的最新研究结果。为评估该模型而进行的动物实验结果表明，除了药理学因素外，条件性药物预期反应也会影响海洛因诱发的死亡率。
